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        Frontier Technology & Research  

         

        It has been the Next Generation Sequencing (NGS) Era for the past 5 years. The fast grow of NGS triggered the entire industry chain of molecular diagnosis and personalized medicine. As functional forms of disease-associated genes, proteins encoded by such genes play critical roles in the initiation and progression of diseases. However, lack of protein-level validation and study of disease-associated genes delays the clinical usage of these genes. Therefore, proteomic investigation of disease-associated genes is the key step in the post-genome era.